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The recombinant Human COMT was expressed with the amino acid range of 52-271. This COMT protein is theoretically predicted to have a molecular weight of 28.3 kDa. This protein is generated in a e.coli-based system. The COMT gene fragment has been modified by fusing the N-terminal 6xHis tag, providing convenience in detecting and purifying the recombinant COMT protein during the following stages.The human catechol O-methyltransferase (COMT) is a crucial enzyme involved in the metabolism of catecholamines, including dopamine, norepinephrine, and epinephrine. Its primary function is the methylation of catechol groups, playing a vital role in regulating neurotransmitter levels in the brain. The COMT gene exhibits polymorphisms, influencing enzyme activity and impacting cognitive and emotional processes. Research on COMT extends to neuropsychiatric disorders such as schizophrenia, bipolar disorder, and mood disorders, exploring associations between genetic variations and susceptibility to these conditions. Additionally, COMT inhibitors are investigated as potential therapeutics, contributing to advancements in neuropharmacology and personalized medicine. Understanding the multifaceted functions of COMT provides valuable insights into neurotransmitter regulation and its implications for mental health and therapeutic interventions.
The recombinant Human COMT was expressed with the amino acid range of 52-271. This COMT protein is theoretically predicted to have a molecular weight of 28.3 kDa. This protein is generated in a e.coli-based system. The COMT gene fragment has been modified by fusing the N-terminal 6xHis tag, providing convenience in detecting and purifying the recombinant COMT protein during the following stages.The human catechol O-methyltransferase (COMT) is a crucial enzyme involved in the metabolism of catecholamines, including dopamine, norepinephrine, and epinephrine. Its primary function is the methylation of catechol groups, playing a vital role in regulating neurotransmitter levels in the brain. The COMT gene exhibits polymorphisms, influencing enzyme activity and impacting cognitive and emotional processes. Research on COMT extends to neuropsychiatric disorders such as schizophrenia, bipolar disorder, and mood disorders, exploring associations between genetic variations and susceptibility to these conditions. Additionally, COMT inhibitors are investigated as potential therapeutics, contributing to advancements in neuropharmacology and personalized medicine. Understanding the multifaceted functions of COMT provides valuable insights into neurotransmitter regulation and its implications for mental health and therapeutic interventions.
| Cat.No | ACP02340 | Target Name | COMT |
|---|---|---|---|
| Target Synonyms | Catechol O methyltransferase; Catechol O-methyltransferase; COMT; COMT_HUMAN; EC 2.1.1.6 | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 52-271aa |
| Mol Weight | 28.3kDa | Protein Length | Partial |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P21964 |
|---|
Uniprot Id
P21964
Target Species
Human
Target Name
COMT
Target Full Name
Catechol O-methyltransferase
Target Function
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
Target Involvement
Schizophrenia (SCZD)
Target Subcellular Location
[Isoform Soluble]: Cytoplasm.; [Isoform Membrane-bound]: Cell membrane; Single-pass type II membrane protein; Extracellular side.
Target Protein Families
Class I-like SAM-binding methyltransferase superfamily, Cation-dependent O-methyltransferase family
Target Tissue Specificity
Brain, liver, placenta, lymphocytes and erythrocytes.
Target Research Area
Metabolism
Target Synonyms
Catechol O methyltransferase; Catechol O-methyltransferase; COMT; COMT_HUMAN; EC 2.1.1.6
Target Background
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.
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