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The recombinant human Fructose-1,6-bisphosphatase 1 (FBP1) is expressed in E. coli, covering the full-length human FBP1 protein sequence (1-338aa). It carries an N-terminal GST tag for efficient purification and exhibits a purity level greater than 90% as determined by SDS-PAGE. This recombinant human FBP1 protein finds applications in the fields of epigenetics and nuclear signaling, where it can be utilized to study glucose metabolism, histone modifications, chromatin structure, and nuclear signaling pathways. Researchers can use this recombinant human FBP1 protein to investigate the enzymatic activity, protein-protein interactions, and functional consequences of FBP1 in cellular processes.
The recombinant human Fructose-1,6-bisphosphatase 1 (FBP1) is expressed in E. coli, covering the full-length human FBP1 protein sequence (1-338aa). It carries an N-terminal GST tag for efficient purification and exhibits a purity level greater than 90% as determined by SDS-PAGE. This recombinant human FBP1 protein finds applications in the fields of epigenetics and nuclear signaling, where it can be utilized to study glucose metabolism, histone modifications, chromatin structure, and nuclear signaling pathways. Researchers can use this recombinant human FBP1 protein to investigate the enzymatic activity, protein-protein interactions, and functional consequences of FBP1 in cellular processes.
| Cat.No | ACP02684 | Target Name | FBP1 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 1-338aa | Mol Weight | 63.7kDa |
| Protein Length | Full length | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P09467 |
|---|
Uniprot Id
P09467
Target Species
Human
Target Name
FBP1
Target Full Name
Fructose-1,6-bisphosphatase 1
Target Function
Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.
Target Involvement
Fructose-1,6-bisphosphatase deficiency (FBP1D)
Target Protein Families
FBPase class 1 family
Target Tissue Specificity
Expressed in pancreatic islets.
Target Research Area
Signal Transduction, Epigenetics and Nuclear Signaling
Target Synonyms
6-bisphosphatase 1; 6-bisphosphate 1-phosphohydrolase 1; D fructose 1 6 bisphosphate 1 phosphohydrolase 1; D-fructose-1; EC 3.1.3.11; F16P1_HUMAN; FBP; FBP 1; FBP1; FBPase 1; Fructose 1 6 bisphosphatase 1; Fructose bisphosphatase 1; Fructose-1; Growth inhibiting protein 17; Liver fructose bisphosphatase
Target Background
Fructose-1, 6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1, 6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1, 6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis.
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