Recombinant Human Hyaluronan-binding protein 2 (HABP2), Truncated

The expression region of this recombinant Human HABP2 covers amino acids 314-560. This HABP2 protein is theoretically predicted to have a molecular weight of 43.3 kDa. This HABP2 recombinant protein is manufactured in e.coli. Fusion of the N-terminal 6xHis-SUMO tag into the HABP2 encoding gene fragment was conducted, allowing for easier detection and purification of the HABP2 protein in subsequent stages.Human hyaluronan-binding protein 2 (HABP2) serves various functions, including its role in coagulation, fibrinolysis, and extracellular matrix interactions. As a serine protease, HABP2 participates in blood clotting regulation, influencing thrombosis and hemostasis. In cancer research, HABP2 is implicated in tumor progression and metastasis, serving as a potential biomarker. In cardiovascular studies, it plays a role in arterial thrombosis. Additionally, HABP2 is linked to skin aging and wound healing. Investigating HABP2 contributes to understanding its multifaceted roles in physiological processes and offers potential insights for developing therapeutic strategies in coagulation disorders, cancer, cardiovascular diseases, and skin-related conditions.

ACP02804

Number

Cat.No	ACP02804	Target Name	HABP2
Form	Liquid or Lyophilized powder	Expression System	E.coli
Expression Range	314-560aa	Mol Weight	43.3kDa
Protein Length	Partial	Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP02804

Target Name

HABP2

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

314-560aa

Mol Weight

43.3kDa

Protein Length

Partial

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q14520

Background Information

Uniprot Id

Q14520
Target Species

Human
Target Name

HABP2
Target Full Name

Hyaluronan-binding protein 2
Target Function

Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII. May function as a tumor suppressor negatively regulating cell proliferation and cell migration.
Target Involvement

Thyroid cancer, non-medullary, 5 (NMTC5)
Target Subcellular Location

Secreted. Note=Secreted as an inactive single-chain precursor and is then activated to a heterodimeric form.
Target Protein Families

Peptidase S1 family
Target Tissue Specificity

Ubiquitously expressed.
Target Research Area

Cardiovascular
Target Synonyms

Factor seven activating protease; Factor seven-activating protease; Factor VII activating protein; Factor VII-activating protease; FSAP; HABP 2; HABP; Habp2; HABP2_HUMAN; Hepatocyte growth factor activator like protein; Hepatocyte growth factor activator-like protein; HGFAL; Hyaluronan binding protein 2; Hyaluronan-binding protein 2 27 kDa light chain alternate form; Hyaluronic acid binding protein 2; PHBP; Plasma hyaluronan binding protein; Plasma hyaluronan-binding protein
Target Background

This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by hepatocytes and proteolytically processed to generate heavy and light chains that form the mature heterodimer. Further autoproteolysis leads to smaller, inactive peptides. This extracellular protease binds hyaluronic acid and may play a role in the coagulation and fibrinolysis systems. Mutations in this gene are associated with nonmedullary thyroid cancer and susceptibility to venous thromboembolism. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed.

Recombinant Human Hyaluronan-binding protein 2 (HABP2), Truncated

Specifications

Immunogen Information

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