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Recombinant Human INMT?protein is a prokaryotic system E.coli expressed Full Length?protein. To make this INMT?recombinant protein, the INMT gene is synthesized and cloned into the E.coli system expression vector, and then it was transformed into protein-expressing host E Coli for expression, the other steps are testing for the identification of recombinant protein, large scale production and target protein Isolation and purification. The purity of the final INMT protein is 90%+?as determined by SDS-PAGE.INMT is a protein encoding gene that provides an instruction in making a protein named Indolethylamine N-methyltransferase. The protein encoded by this gene is also known as aromatic alkylamine N-methyltransferase or thioether S-methyltransferase (short name is TEMT). It belongs to a Class 1 transmethylation enzyme that is known for its production of N,N-dimethyltryptamine (DMT), a hallucinogen with affinity for various serotonergic, adrenergic, histaminergic, dopaminergic, and sigma-1 receptors. It has been reported involving in amine metabolic process, methylation and response to toxic substance.
Recombinant Human INMT?protein is a prokaryotic system E.coli expressed Full Length?protein. To make this INMT?recombinant protein, the INMT gene is synthesized and cloned into the E.coli system expression vector, and then it was transformed into protein-expressing host E Coli for expression, the other steps are testing for the identification of recombinant protein, large scale production and target protein Isolation and purification. The purity of the final INMT protein is 90%+?as determined by SDS-PAGE.INMT is a protein encoding gene that provides an instruction in making a protein named Indolethylamine N-methyltransferase. The protein encoded by this gene is also known as aromatic alkylamine N-methyltransferase or thioether S-methyltransferase (short name is TEMT). It belongs to a Class 1 transmethylation enzyme that is known for its production of N,N-dimethyltryptamine (DMT), a hallucinogen with affinity for various serotonergic, adrenergic, histaminergic, dopaminergic, and sigma-1 receptors. It has been reported involving in amine metabolic process, methylation and response to toxic substance.
| Cat.No | ACP04246 | Target Name | INMT |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 1-263aa | Mol Weight | 44.9kDa |
| Protein Length | Full length | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O95050 |
|---|
Uniprot Id
O95050
Target Species
Human
Target Name
INMT
Target Full Name
Indolethylamine N-methyltransferase
Target Function
Functions as thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2-methylthioethylamine, 2-methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide. Plays an important role in the detoxification of selenium compounds. Catalyzes the N-methylation of tryptamine and structurally related compounds.
Target Subcellular Location
Cytoplasm.
Target Protein Families
Class I-like SAM-binding methyltransferase superfamily, NNMT/PNMT/TEMT family
Target Tissue Specificity
Widely expressed. The highest levels were in thyroid, adrenal gland, adult and fetal lung. Intermediate levels in heart, placenta, skeletal muscle, testis, small intestine, pancreas, stomach, spinal cord, lymph node and trachea. Very low levels in adult a
Target Research Area
Metabolism
Target Synonyms
Amine N methyltransferase; Amine N-methyltransferase; Aromatic alkylamine N methyltransferase; Aromatic alkylamine N-methyltransferase; Arylamine N methyltransferase; Arylamine N-methyltransferase; Indolamine N-methyltransferase; Indolethylamine N methyltransferase; Indolethylamine N-methyltransferase; Inmt; INMT_HUMAN; nicotine N methyltransferase ; TEMT; thioester S methyltransferase like; Thioether S methyltransferase
Target Background
N-methylation of endogenous and xenobiotic compounds is a major method by which they are degraded. This gene encodes an enzyme that N-methylates indoles such as tryptamine. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream MINDY4 (aka FAM188B) gene. In rodents and other mammals such as cetartiodactyla this gene is in the opposite orientation compared to its orientation in human and other primates and this gene appears to have been lost in carnivora and chiroptera.
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