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The fusion tag N-terminal 6xHis tag gene was added to the gene sequence corresponding to the yeast of the human TPO protein to form the recombinant DNA. The recombinant DNA was cloned into the expression vector and then transfected into the yeast cells for expression. Following purification, the product is the recombinant human TPO protein carrying N-terminal 6xHis tag. The SDS-PAGE assessed the purity of this recombinant TPO protein up to 90%. It had an apparent molecular weight of approximately 40 kDa. This recombinant TPO protein may be used in the research of TPO-related cancer.TPO is a gene providing instructions for making a protein named thyroid peroxidase (abbreviated TPO) in human and belongs to peroxidase family and XPO subfamily. TPO is an enzyme normally found in the thyroid gland, plays an important role in the production of thyroid hormones. TPO is found in thyroid follicle cells where it converts the thyroid hormone T4 to T3. In clinic, the presence of TPO antibodies in your blood suggests that the cause of thyroid disease is an autoimmune disorder, such as Hashimoto's disease or Graves' disease.
The fusion tag N-terminal 6xHis tag gene was added to the gene sequence corresponding to the yeast of the human TPO protein to form the recombinant DNA. The recombinant DNA was cloned into the expression vector and then transfected into the yeast cells for expression. Following purification, the product is the recombinant human TPO protein carrying N-terminal 6xHis tag. The SDS-PAGE assessed the purity of this recombinant TPO protein up to 90%. It had an apparent molecular weight of approximately 40 kDa. This recombinant TPO protein may be used in the research of TPO-related cancer.TPO is a gene providing instructions for making a protein named thyroid peroxidase (abbreviated TPO) in human and belongs to peroxidase family and XPO subfamily. TPO is an enzyme normally found in the thyroid gland, plays an important role in the production of thyroid hormones. TPO is found in thyroid follicle cells where it converts the thyroid hormone T4 to T3. In clinic, the presence of TPO antibodies in your blood suggests that the cause of thyroid disease is an autoimmune disorder, such as Hashimoto’s disease or Graves’ disease.
| Cat.No | ACP04713 | Target Name | TPO |
|---|---|---|---|
| Target Synonyms | MSA ; PERT_HUMAN; TDH2A; Thyroid microsomal antigen; Thyroid peroxidase; Thyroperoxidase; TPO; TPX | Form | Liquid or Lyophilized powder |
| Expression System | Yeast | Expression Range | 19-161aa |
| Mol Weight | 17.9kDa | Protein Length | Partial |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P07202 |
|---|
Uniprot Id
P07202
Target Species
Human
Target Name
TPO
Target Full Name
Thyroid peroxidase
Target Function
Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).
Target Involvement
Thyroid dyshormonogenesis 2A (TDH2A)
Target Subcellular Location
Membrane; Single-pass type I membrane protein.; [Isoform 3]: Cell surface.
Target Protein Families
Peroxidase family, XPO subfamily
Target Research Area
Cancer
Target Synonyms
MSA ; PERT_HUMAN; TDH2A; Thyroid microsomal antigen; Thyroid peroxidase; Thyroperoxidase; TPO; TPX
Target Background
This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined.
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