Recombinant Human P2X purinoceptor 2 (P2RX2), Truncated

Uniprot Id

Q9UBL9

Target Species

Human

Target Name

P2RX2

Target Full Name

P2X purinoceptor 2

Target Function

Ion channel gated by extracellular ATP involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle.

Target Involvement

Deafness, autosomal dominant, 41 (DFNA41)

Target Subcellular Location

Cell membrane; Multi-pass membrane protein. Note=Localizes to the apical membranes of hair cells in the organ of Corti.

Target Protein Families

P2X receptor family

Target Synonyms

ATP receptor; MGC129601; P2RX 2; P2RX2; P2RX2_HUMAN; P2X purinoceptor 2; P2X Receptor subunit 2; P2X2; P2X2a; Purinergic receptor; Purinergic receptor P2X ligand gated ion channel 2; Purinergic receptor P2X2 isoform A; Purinergic receptor P2X2 isoform B; Purinergic receptor P2X2 isoform C; Purinergic receptor P2X2 isoform D; Purinergic receptor P2X2 isoform H; Purinergic receptor P2X2 isoform I

Target Background

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Multiple transcript variants encoding distinct isoforms have been identified for this gene.