Recombinant Human Solute carrier family 40 member 1 (SLC40A1), Truncated

Uniprot Id

Q9NP59

Target Species

Human

Target Name

SLC40A1

Target Full Name

Ferroportin

Target Function

Major iron transporter that plays a key role in balancing cellular and systemic iron levels. Transports iron from intestinal, splenic, and hepatic cells into the blood to provide iron to other tissues. Controls therefore dietary iron uptake, iron recycling by macrophages, and release of iron stores in hepatocytes. When iron is in excess, hepcidin/HAMP levels increase resulting in a degradation of ferroportin/SLC40A1 limiting the iron efflux to plasma.

Target Involvement

Hemochromatosis 4 (HFE4)

Target Subcellular Location

Cell membrane; Multi-pass membrane protein. Note=Localized to the basolateral membrane of polarized epithelial cells.

Target Protein Families

Ferroportin (FP) (TC 2.A.100) family, SLC40A subfamily

Target Tissue Specificity

Detected in erythrocytes (at protein level). Expressed in placenta, intestine, muscle and spleen.

Target Synonyms

Ferroportin 1; Ferroportin; Ferroportin-1; FPN1; HFE4; IREG1; iron regulated gene 1; Iron regulated transporter 1 ; Iron-regulated transporter 1; MST079; MSTP079; MTP1; putative ferroportin 1 variant IIIA; putative ferroportin 1 variant IIIB; S40A1_HUMAN; SLC11A3; SLC11A3; formerly; SLC40A1; solute carrier family 11 (proton-coupled divalent metal ion transporters); member 3; solute carrier family 11 (proton-coupled divalent metal ion transporters); member 3; formerly; solute carrier family 40 (iron-regulated transporter); member 1; Solute carrier family 40 member 1

Target Background

The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4).