Recombinant Human Solute carrier family 13 member 3 (SLC13A3), Truncated

Uniprot Id

Q8WWT9

Target Species

Human

Target Name

SLC13A3

Target Full Name

Na(+)/dicarboxylate cotransporter 3

Target Function

High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-6 carbon atoms, including succinate, alpha-ketoglutarate and N-acetylaspartate. The stoichiometry is probably 3 Na(+) for 1 divalent succinate.

Target Subcellular Location

Cell membrane; Multi-pass membrane protein.

Target Protein Families

SLC13A/DASS transporter (TC 2.A.47) family, NADC subfamily

Target Tissue Specificity

Expression is highest in kidney. Detected in placenta, brain, liver and pancreas.

Target Synonyms

dicarboxylate cotransporter 3; H sapiens mRNA for hepatocyte nuclear factor 4 gamma; hNaDC3; Na; Na(+)/dicarboxylate cotransporter 3; NaDC 3; NaDC-3; NADC3; S13A3_HUMAN; SDCT 2; SDCT2; SLC13A3; Sodium dependent high affinity dicarboxylate transporter 2; Sodium dependent high affinity dicarboxylate transporter 3; Sodium-dependent high-affinity dicarboxylate transporter 2; Solute carrier family 13 (sodium dependent dicarboxylate transporter); member 3; Solute carrier family 13 member 3

Target Background

Mammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity transporters play an important role in the handling of citrate by the kidneys. The protein encoded by this gene represents the high-affinity form. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been characterized yet.