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| Cat.No | ACP06513 | Target Name | ECE1 |
|---|---|---|---|
| Target Synonyms | ECE1; Endothelin-converting enzyme 1 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P42892 |
|---|
Uniprot Id
P42892
Target Species
Human
Target Name
ECE1
Target Full Name
Endothelin-converting enzyme 1
Target Function
Converts big endothelin-1 to endothelin-1.
Target Involvement
Hirschsprung disease, cardiac defects, and autonomic dysfunction (HCAD)
Target Subcellular Location
Cell membrane; Single-pass type II membrane protein.
Target Protein Families
Peptidase M13 family
Target Tissue Specificity
All isoforms are expressed in umbilical vein endothelial cells, polynuclear neutrophils, fibroblasts, atrium cardiomyocytes and ventricles. Isoforms A, B and C are also expressed in placenta, lung, heart, adrenal gland and phaeochromocytoma; isoforms A an
Target Synonyms
ECE1; Endothelin-converting enzyme 1
Target Background
The protein encoded by this gene is involved in proteolytic processing of endothelin precursors to biologically active peptides. Mutations in this gene are associated with Hirschsprung disease, cardiac defects and autonomic dysfunction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
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