Recombinant Human 5-hydroxytryptamine receptor 1A (HTR1A), Truncated

Uniprot Id

P08908

Target Species

Human

Target Name

HTR1A

Target Full Name

5-hydroxytryptamine receptor 1A

Target Function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.

Target Involvement

Periodic fever, menstrual cycle-dependent (PFMC)

Target Subcellular Location

Cell membrane; Multi-pass membrane protein. Cell projection, dendrite.

Target Protein Families

G-protein coupled receptor 1 family, 5-hydroxytryptamine receptor subfamily, HTR1A sub-subfamily

Target Tissue Specificity

Detected in lymph nodes, thymus and spleen. Detected in activated T-cells, but not in resting T-cells.

Target Synonyms

HTR1A; ADRB2RL1; ADRBRL1; 5-hydroxytryptamine receptor 1A; 5-HT-1A; 5-HT1A; G-21; Serotonin receptor 1A

Target Background

This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers.