Recombinant Human G-protein coupled receptor 143 (GPR143), Truncated

Uniprot Id

P51810

Target Species

Human

Target Name

GPR143

Target Full Name

G-protein coupled receptor 143

Target Function

Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand-dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport.

Target Involvement

Albinism ocular 1 (OA1); Nystagmus congenital X-linked 6 (NYS6)

Target Subcellular Location

Melanosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein.

Target Protein Families

G-protein coupled receptor OA family

Target Tissue Specificity

Expressed at high levels in the retina, including the retinal pigment epithelium (RPE), and in melanocytes. Weak expression is observed in brain and adrenal gland.

Target Synonyms

GPR143; OA1; G-protein coupled receptor 143; Ocular albinism type 1 protein

Target Background

This gene encodes a protein that binds to heterotrimeric G proteins and is targeted to melanosomes in pigment cells. This protein is thought to be involved in intracellular signal transduction mechanisms. Mutations in this gene cause ocular albinism type 1, also referred to as Nettleship-Falls type ocular albinism, a severe visual disorder. A related pseudogene has been identified on chromosome Y.