Recombinant Human RPE-retinal G protein-coupled receptor (RGR), Truncated

Uniprot Id

P47804

Target Species

Human

Target Name

RGR

Target Full Name

RPE-retinal G protein-coupled receptor

Target Function

Receptor for all-trans- and 11-cis-retinal. Binds preferentially to the former and may catalyze the isomerization of the chromophore by a retinochrome-like mechanism.

Target Involvement

Retinitis pigmentosa 44 (RP44)

Target Subcellular Location

Membrane; Multi-pass membrane protein.

Target Protein Families

G-protein coupled receptor 1 family, Opsin subfamily

Target Tissue Specificity

Preferentially expressed at high levels in the retinal pigment epithelium (RPE) and Mueller cells of the neural retina.

Target Synonyms

RGR; RPE-retinal G protein-coupled receptor

Target Background

This gene encodes a putative retinal G-protein coupled receptor. The gene is a member of the opsin subfamily of the 7 transmembrane, G-protein coupled receptor 1 family. Like other opsins which bind retinaldehyde, it contains a conserved lysine residue in the seventh transmembrane domain. The protein acts as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. The reverse isomerization occurs with rhodopsin in retinal photoreceptor cells. The protein is exclusively expressed in tissue adjacent to retinal photoreceptor cells, the retinal pigment epithelium and Mueller cells. This gene may be associated with autosomal recessive and autosomal dominant retinitis pigmentosa (arRP and adRP, respectively). Alternative splicing results in multiple transcript variants encoding different isoforms.