Recombinant Human Fatty-acid amide hydrolase 2 (FAAH2), Truncated

Uniprot Id

Q6GMR7

Target Species

Human

Target Name

FAAH2

Target Full Name

Fatty-acid amide hydrolase 2

Target Function

Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides, to their corresponding fatty acids, thereby regulating the signaling functions of these molecules. Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substrates.

Target Subcellular Location

Membrane; Single-pass membrane protein. Lipid droplet.

Target Protein Families

Amidase family

Target Tissue Specificity

Expressed in kidney, liver, lung, prostate, heart and ovary.

Target Synonyms

FAAH2; AMDD; Fatty-acid amide hydrolase 2; Amidase domain-containing protein; Anandamide amidohydrolase 2; Oleamide hydrolase 2

Target Background

This gene encodes a fatty acid amide hydrolase that shares a conserved protein motif with the amidase signature family of enzymes. The encoded enzyme is able to catalyze the hydrolysis of a broad range of bioactive lipids, including those from the three main classes of fatty acid amides; N-acylethanolamines, fatty acid primary amides and N-acyl amino acids. This enzyme has a preference for monounsaturated acyl chains as a substrate. Alternate splicing results in multiple transcript variants encoding distinct isoforms.