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| Cat.No | ACP08446 | Target Name | OCLN |
|---|---|---|---|
| Target Synonyms | OCLN; Occludin | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q16625 |
|---|
Uniprot Id
Q16625
Target Species
Human
Target Name
OCLN
Target Full Name
Occludin
Target Function
May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions.; (Microbial infection) Acts as a co-receptor for hepatitis C virus (HCV) in hepatocytes.
Target Involvement
Pseudo-TORCH syndrome 1 (PTORCH1)
Target Subcellular Location
Cell membrane; Multi-pass membrane protein. Cell junction, tight junction.
Target Protein Families
ELL/occludin family
Target Tissue Specificity
Localized at tight junctions of both epithelial and endothelial cells. Highly expressed in kidney. Not detected in testis.
Target Synonyms
OCLN; Occludin
Target Background
This gene encodes an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. Mutations in this gene are thought to be a cause of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG), an autosomal recessive neurologic disorder that is also known as pseudo-TORCH syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene is present 1.5 Mb downstream on the q arm of chromosome 5.
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