Recombinant Human Calpastatin (CAST)

Uniprot Id

P20810

Target Species

Human

Target Name

CAST

Target Full Name

Calpastatin

Target Function

Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.

Target Involvement

Peeling skin with leukonychia, acral punctate keratoses, cheilitis, and knuckle pads (PLACK)

Target Protein Families

Protease inhibitor I27 (calpastatin) family

Target Research Area

Neuroscience

Target Synonyms

BS 17; Calpain inhibitor; Calpastatin; Cast; Heart type calpastatin ; ICAL_HUMAN; MGC9402; Sperm BS 17 component ; Sperm BS-17 component

Target Background

The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described.