Recombinant Human Suppressor of SWI4 1 homolog (PPAN)

Uniprot Id

Q9NQ55

Target Species

Human

Target Name

PPAN

Target Full Name

Suppressor of SWI4 1 homolog

Target Function

May have a role in cell growth.

Target Subcellular Location

Nucleus, nucleolus.

Target Tissue Specificity

Widely expressed.

Target Research Area

Epigenetics and Nuclear Signaling

Target Synonyms

Brix domain containing protein 3; Brix domain-containing protein 3; BXDC3; Homolog of S. cerevisiae SSF1; Peter pan homolog (Drosophila); Peter Pan homolog; PPAN; Second step splicing factor 1; SSF 1; SSF; Ssf-1; SSF1; SSF1_HUMAN; SSF2; Suppressor of sterile four 1; Suppressor of SWI4 1 homolog

Target Background

The protein encoded by this gene is an evolutionarily conserved protein similar to yeast SSF1 as well as to the gene product of the Drosophila gene peter pan (ppan). SSF1 is known to be involved in the second step of mRNA splicing. Both SSF1 and ppan are essential for cell growth and proliferation. Exogenous expression of this gene was reported to reduce the anchorage-independent growth of some tumor cells. Read-through transcription of this gene with P2RY11/P2Y(11), an adjacent downstream gene that encodes an ATP receptor, has been found. These read-through transcripts are ubiquitously present and up-regulated during granulocyte differentiation.