Recombinant Human Gelsolin (GSN), E.coli

Uniprot Id

P06396

Target Species

Human

Target Name

GSN

Target Full Name

Gelsolin

Target Function

Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.

Target Involvement

Amyloidosis 5 (AMYL5)

Target Subcellular Location

[Isoform 2]: Cytoplasm, cytoskeleton.; [Isoform 1]: Secreted.

Target Protein Families

Villin/gelsolin family

Target Tissue Specificity

Phagocytic cells, platelets, fibroblasts, nonmuscle cells, smooth and skeletal muscle cells.

Target Research Area

Signal Transduction

Target Synonyms

Actin depolymerizing factor; Actin-depolymerizing factor; ADF; AGEL; Brevin; DKFZp313L0718; GELS_HUMAN; Gelsolin; Gsn

Target Background

The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene.