Recombinant Human Microtubule-associated protein RP/EB family member 3 (MAPRE3)

Uniprot Id

Q9UPY8

Target Species

Human

Target Name

MAPRE3

Target Full Name

Microtubule-associated protein RP/EB family member 3

Target Function

Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules. May play a role in cell migration.

Target Subcellular Location

Cytoplasm, cytoskeleton.

Target Protein Families

MAPRE family

Target Tissue Specificity

Predominantly expressed in brain and muscle.

Target Synonyms

APC binding protein ; EB 3; EB1 protein family member 3; EB3; EBF 3; EBF-3; EBF3; EBF3 S; End binding protein 3 ; End-binding protein 3; MAPRE 3; MAPRE3; MARE3_HUMAN; Member 3; Microtubule Associated Protein; Microtubule associated protein RP/EB family member 3; Microtubule-associated protein RP/EB family member 3; OTTHUMP00000200910; RP 3; RP/EB Family; RP3

Target Background

The protein encoded by this gene is a member of the RP/EB family of genes. The protein localizes to the cytoplasmic microtubule network and binds APCL, a homolog of the adenomatous polyposis coli tumor suppressor gene.