Recombinant Human Glioma tumor suppressor candidate region gene 2 protein (GLTSCR2)

Cat.No	ACP10527	Target Name	NOP53
Target Synonyms	Glioma tumor suppressor candidate region gene 2 protein; GLTSCR2; GSCR2_HUMAN; p60; PICT1; protein interacting with carboxyl terminus 1	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	2-478
Protein Length	Full Length of Mature Protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP10527

Target Name

NOP53

Target Synonyms

Glioma tumor suppressor candidate region gene 2 protein; GLTSCR2; GSCR2_HUMAN; p60; PICT1; protein interacting with carboxyl terminus 1

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

2-478

Protein Length

Full Length of Mature Protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9NZM5

Background Information

Uniprot Id

Q9NZM5
Target Species

Human
Target Name

NOP53
Target Full Name

Ribosome biogenesis protein NOP53
Target Function

Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis. In ribosome biogenesis, may also play a role in rRNA transcription. Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in response to ribosome biogenesis perturbation, DNA damage and other stress conditions. DNA damage or perturbation of ribosome biogenesis disrupt the interaction between NOP53 and RPL11 allowing RPL11 transport to the nucleoplasm where it can inhibit MDM2 and allow p53/TP53 activation. It may also positively regulate the function of p53/TP53 in cell cycle arrest and apoptosis through direct interaction, preventing its MDM2-dependent ubiquitin-mediated proteasomal degradation. Originally identified as a tumor suppressor, it may also play a role in cell proliferation and apoptosis by positively regulating the stability of PTEN, thereby antagonizing the PI3K-AKT/PKB signaling pathway. May also inhibit cell proliferation and increase apoptosis through its interaction with NF2. May negatively regulate NPM1 by regulating its nucleoplasmic localization, oligomerization and ubiquitin-mediated proteasomal degradation. Thereby, may prevent NPM1 interaction with MYC and negatively regulate transcription mediated by the MYC-NPM1 complex. May also regulate cellular aerobic respiration. In the cellular response to viral infection, may play a role in the attenuation of interferon-beta through the inhibition of DDX58/RIG-1.
Target Subcellular Location

Nucleus, nucleolus. Nucleus, nucleoplasm.
Target Protein Families

NOP53 family
Target Tissue Specificity

Expressed at high levels in heart and pancreas, moderate levels in placenta, liver, skeletal muscle, and kidney, and low levels in brain and lung.
Target Synonyms

Glioma tumor suppressor candidate region gene 2 protein; GLTSCR2; GSCR2_HUMAN; p60; PICT1; protein interacting with carboxyl terminus 1

Recombinant Human Glioma tumor suppressor candidate region gene 2 protein (GLTSCR2)

Specifications

Immunogen Information

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