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Recombinant Human Cadherin-related family member 2 (CDHR2), Truncated

ACP11049

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Specifications

Cat.No	ACP11049	Target Name	CDHR2
Target Synonyms	CDHR2; PCDH24; PCLKCCadherin-related family member 2; Protocadherin LKC; PC-LKC; Protocadherin-24	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Protein Length	Partial
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q9BYE9

Background Information

Uniprot Id

Q9BYE9
Target Species

Human
Target Name

CDHR2
Target Full Name

Cadherin-related family member 2
Target Function

Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR5 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation. May also play a role in cell-cell adhesion and contact inhibition in epithelial cells.
Target Subcellular Location

Apical cell membrane; Single-pass type I membrane protein. Cell projection, microvillus membrane; Single-pass type I membrane protein. Cell junction.
Target Tissue Specificity

Highly expressed in liver, kidney and colon. Moderately expressed in small intestine. Down-regulated in a number of liver and colon cancers. Expressed in duodenum with higher expression in enterocytes along the villus axis and lower expression in crypts (
Target Synonyms

CDHR2; PCDH24; PCLKCCadherin-related family member 2; Protocadherin LKC; PC-LKC; Protocadherin-24

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Recombinant Human Cadherin-related family member 2 (CDHR2), Truncated

Specifications

Immunogen Information

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