Recombinant Human Guanine nucleotide-binding protein-like 3 (GNL3)

Uniprot Id

Q9BVP2

Target Species

Human

Target Name

GNL3

Target Full Name

Guanine nucleotide-binding protein-like 3

Target Function

May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation.

Target Subcellular Location

Nucleus. Nucleus, nucleolus.

Target Protein Families

TRAFAC class YlqF/YawG GTPase family

Target Tissue Specificity

Increased levels in lung tissue in cancer patients.

Target Synonyms

C77032 ; E2 induced gene 3 protein; E2-induced gene 3 protein; E2IG3; Estradiol induced nucleotide binding protein; GNL3; GNL3_HUMAN; Guanine nucleotide binding protein like 3 (nucleolar); Guanine nucleotide binding protein like 3; Guanine nucleotide-binding protein-like 3; MGC800; NNP47; Novel nucleolar protein 47; NS; Nucleolar GTP binding protein 3 ; Nucleolar GTP-binding protein 3; Nucleostemin; Putative nucleotide binding protein estradiol induced

Target Background

The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene.