Recombinant Human Peroxisomal 2,4-dienoyl-CoA reductase (DECR2)

Uniprot Id

Q9NUI1

Target Species

Human

Target Name

DECR2

Target Full Name

Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]

Target Function

Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid.

Target Subcellular Location

Peroxisome.

Target Protein Families

Short-chain dehydrogenases/reductases (SDR) family, 2,4-dienoyl-CoA reductase subfamily

Target Synonyms

2 4 dienoyl CoA reductase 2; 2 4 dienoyl CoA reductase 2 peroxisomal; 2; 4-dienoyl-CoA reductase 2; 4-dienoyl-CoA reductase; DECR 2; Decr2; DECR2_HUMAN; EC 1.3.1.34; pDCR; Peroxisomal 2 4 dienoyl CoA reductase; Peroxisomal 2; SDR17C1; Short chain dehydrogenase/reductase family 17C member 1

Target Background

Enables 2, 4-dienoyl-CoA reductase (NADPH) activity and trans-2-enoyl-CoA reductase (NADPH) activity. Involved in unsaturated fatty acid biosynthetic process. Predicted to be located in peroxisome.