Recombinant Human Inositol polyphosphate 5-phosphatase K (INPP5K)

Uniprot Id

Q9BT40

Target Species

Human

Target Name

INPP5K

Target Full Name

Inositol polyphosphate 5-phosphatase K

Target Function

Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate. Negatively regulates assembly of the actin cytoskeleton. Controls insulin-dependent glucose uptake among inositol 3,4,5-trisphosphate phosphatases; therefore, is the specific regulator for insulin signaling in skeletal muscle.

Target Involvement

Muscular dystrophy, congenital, with cataracts and intellectual disability (MDCCAID)

Target Subcellular Location

Endoplasmic reticulum. Cytoplasm.

Target Protein Families

Inositol 1,4,5-trisphosphate 5-phosphatase type II family

Target Tissue Specificity

Ubiquitously expressed with highest levels in skeletal muscle, heart and kidney.

Target Synonyms

43 kDa form skeletal muscle and kidney enriched inositol phosphatase; Inositol polyphosphate 5-phosphatase K; INP5K_HUMAN; INPP5K; muscle and kidney-enriched inositol phosphatase; PPS; skeletal muscle and kidney enriched inositol phosphatase; Skeletal muscle and kidney-enriched inositol phosphatase

Target Background

This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternatively spliced transcript variants encoding different isoforms have been identified.