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Recombinant Human Protein LAP2 (ERBB2IP), Truncated

ACP12560

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Specifications

Cat.No	ACP12560	Target Name	ERBIN
Target Synonyms	Densin-180-like protein; Erbb2-interacting protein; Erbb2ip; Erbin; LAP2; LAP2_HUMAN; Protein LAP2	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Protein Length	Partial
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q96RT1

Background Information

Uniprot Id

Q96RT1
Target Species

Human
Target Name

ERBIN
Target Full Name

Erbin
Target Function

Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state. Inhibits NOD2-dependent NF-kappa-B signaling and proinflammatory cytokine secretion.
Target Subcellular Location

Cell junction, hemidesmosome. Nucleus membrane. Basolateral cell membrane.
Target Protein Families

LAP (LRR and PDZ) protein family
Target Tissue Specificity

Highly expressed in brain, heart, kidney, muscle and stomach, followed by liver, spleen and intestine.
Target Synonyms

Densin-180-like protein; Erbb2-interacting protein; Erbb2ip; Erbin; LAP2; LAP2_HUMAN; Protein LAP2
Target Background

This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

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Recombinant Human Protein LAP2 (ERBB2IP), Truncated

Specifications

Immunogen Information

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