Recombinant Human Spermatogenesis-associated protein 13 (SPATA13)

Uniprot Id

Q96N96

Target Species

Human

Target Name

SPATA13

Target Full Name

Spermatogenesis-associated protein 13

Target Function

Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.

Target Subcellular Location

Cytoplasm. Cell projection, filopodium. Cell projection, lamellipodium. Cell projection, ruffle membrane. Note=Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment.

Target Tissue Specificity

Expressed at high levels in the placenta, spleen and kidney, at moderate levels in lung, small intestine, liver, brain and heart, and at low levels in skeletal muscle. Expression is aberrantly enhanced in most colorectal tumors.

Target Synonyms

APC-stimulated guanine nucleotide exchange factor 2; ARHGEF29; Asef2; FLJ31208; RP11-307N16.3; Spata13; Spermatogenesis-associated protein 13; SPT13_HUMAN