Recombinant Human Sorting nexin-27 (SNX27)

Cat.No	ACP13773	Target Name	SNX27
Target Synonyms	KIAA0488; Methamphetamine responsive transcript 1; MGC126871; MGC126873; MGC20471; MRT1; MY014; OTTHUMP00000042487; RP11-98D18.12; SNX27; SNX27_HUMAN; Sorting nexin family member 27; Sorting nexin-27	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	1-541
Protein Length	Full length protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP13773

Target Name

SNX27

Target Synonyms

KIAA0488; Methamphetamine responsive transcript 1; MGC126871; MGC126873; MGC20471; MRT1; MY014; OTTHUMP00000042487; RP11-98D18.12; SNX27; SNX27_HUMAN; Sorting nexin family member 27; Sorting nexin-27

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

1-541

Protein Length

Full length protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q96L92

Background Information

Uniprot Id

Q96L92
Target Species

Human
Target Name

SNX27
Target Full Name

Sorting nexin-27
Target Function

Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes.
Target Subcellular Location

Early endosome membrane; Peripheral membrane protein. Cytoplasm, cytosol. Note=Localizes to immunological synapse in T-cells. In T-cells, recruited from the cytosol to sorting endosomes by phosphoinositide-3-kinase products.
Target Protein Families

Sorting nexin family
Target Tissue Specificity

Widely expressed. Expressed in cells of hematopoietic origin (at protein level).
Target Synonyms

KIAA0488; Methamphetamine responsive transcript 1; MGC126871; MGC126873; MGC20471; MRT1; MY014; OTTHUMP00000042487; RP11-98D18.12; SNX27; SNX27_HUMAN; Sorting nexin family member 27; Sorting nexin-27

Recombinant Human Sorting nexin-27 (SNX27)

Specifications

Immunogen Information

Inquire Recombinant Human Sorting nexin-27 (SNX27) Now

Related Products