Recombinant Human SH2 domain-containing protein 3C (SH2D3C), Truncated

Cat.No	ACP14000	Target Name	SH2D3C
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Protein Length	Partial	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP14000

Target Name

SH2D3C

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q8N5H7

Background Information

Uniprot Id

Q8N5H7
Target Species

Human
Target Name

SH2D3C
Target Full Name

SH2 domain-containing protein 3C
Target Function

Acts as an adapter protein that mediates cell signaling pathways involved in cellular functions such as cell adhesion and migration, tissue organization, and the regulation of the immune response. Plays a role in integrin-mediated cell adhesion through BCAR1-CRK-RAPGEF1 signaling and activation of the small GTPase RAP1. Promotes cell migration and invasion through the extracellular matrix. Required for marginal zone B-cell development and thymus-independent type 2 immune responses. Mediates migration and adhesion of B cells in the splenic marginal zone via promoting hyperphosphorylation of NEDD9/CASL. Plays a role in CXCL13-induced chemotaxis of B-cells. Plays a role in the migration of olfactory sensory neurons (OSNs) into the forebrain and the innervation of the olfactory bulb by the OSN axons during development. Required for the efficient tyrosine phosphorylation of BCAR1 in OSN axons.; Important regulator of chemokine-induced, integrin-mediated T lymphocyte adhesion and migration, acting upstream of RAP1. Required for tissue-specific adhesion of T lymphocytes to peripheral tissues. Required for basal and CXCL2 stimulated serine-threonine phosphorylation of NEDD9. May be involved in the regulation of T-cell receptor-mediated IL2 production through the activation of the JNK pathway in T-cells.; May be involved in the BCAR1/CAS-mediated JNK activation pathway.
Target Subcellular Location

Cytoplasm. Cell membrane; Peripheral membrane protein. Cell projection, axon. Cell projection, ruffle membrane.; [Isoform 1]: Cell membrane; Peripheral membrane protein.
Target Tissue Specificity

[Isoform 1]: Ubiquitously expressed.
Target Synonyms

Cas/HEF1 associated signal transducer; CHAT; FLJ39664; Novel SH2 containing protein 3; Novel SH2-containing protein 3; NSP 3; PRO34088; SH2 domain containing 3C ; SH2 domain containing Eph receptor binding protein 1; SH2 domain containing protein 3C; SH2 domain-containing protein 3C; SH2D3_HUMAN; SH2D3C; Shep1

Recombinant Human SH2 domain-containing protein 3C (SH2D3C), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human SH2 domain-containing protein 3C (SH2D3C), Truncated Now

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