Recombinant Human Protein Hook homolog 3 (HOOK3)

Uniprot Id

Q86VS8

Target Species

Human

Target Name

HOOK3

Target Full Name

Protein Hook homolog 3

Target Function

Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking. Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell.; (Microbial infection) May serve as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking.

Target Subcellular Location

Cytoplasm, cytoskeleton. Golgi apparatus.

Target Protein Families

Hook family

Target Synonyms

FLJ31058; h-hook3; hHK3; HK3; hook3; HOOK3_HUMAN; OTTHUMP00000229200; Protein Hook homolog 3

Target Background

Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.