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Recombinant Human Factor in the germline alpha (FIGLA)

ACP16223

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Specifications

Cat.No	ACP16223	Target Name	FIGLA
Target Synonyms	FIGLA; BHLHC8Factor in the germline alpha; FIGalpha; Class C basic helix-loop-helix protein 8; bHLHc8; Folliculogenesis-specific basic helix-loop-helix protein; Transcription factor FIGa	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	1-219
Protein Length	Full length protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q6QHK4

Background Information

Uniprot Id

Q6QHK4
Target Species

Human
Target Name

FIGLA
Target Full Name

Factor in the germline alpha
Target Function

Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E-box (5'-CANNTG-3') of the ZPs (ZP1, ZP2, ZP3) promoters
Target Involvement

Premature ovarian failure 6 (POF6)
Target Subcellular Location

Nucleus.
Target Tissue Specificity

Germ cells. Expressed in the fetal ovary, but not by a range of other tissues. Expression increases across mid-gestation, rising some 40-fold by the time of primordial follicle formation.
Target Synonyms

FIGLA; BHLHC8Factor in the germline alpha; FIGalpha; Class C basic helix-loop-helix protein 8; bHLHc8; Folliculogenesis-specific basic helix-loop-helix protein; Transcription factor FIGa

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Recombinant Human Factor in the germline alpha (FIGLA)

Specifications

Immunogen Information

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