Recombinant Human Forkhead box protein I1 (FOXI1)

Uniprot Id

Q12951

Target Species

Human

Target Name

FOXI1

Target Full Name

Forkhead box protein I1

Target Function

Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. Also required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 and the differentiation of intercalated cells in the epithelium of distal renal tubules.

Target Subcellular Location

Nucleus.

Target Tissue Specificity

Expressed in kidney.

Target Synonyms

FKH10; FKHL10; Forkhead (Drosophila) like 10; Forkhead box I1; Forkhead box protein I1; Forkhead like 10; Forkhead related activator 6; Forkhead related transcription factor 6; Forkhead-related protein FKHL10; Forkhead-related transcription factor 6; FOXI1; FOXI1_HUMAN; FREAC 6; FREAC-6; FREAC6; Hepatocyte nuclear factor 3 forkhead homolog 3; HFH 3; HFH-3; HFH3; HNF 3/fork head homolog 3; HNF-3 fork-head homolog 3; HNF-3/fork-head homolog 3; Human HNF-3 fork-head homolog-3 HFH-3 mRNA complete cds; MGC34197

Target Background

This gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. This gene may play an important role in the development of the cochlea and vestibulum, as well as in embryogenesis. The encoded protein has been found to be required for the transcription of four subunits of a proton pump found in the inner ear, the kidney, and the epididymis. Mutations in this gene have been associated with deafness, autosomal recessive 4.