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| Cat.No | ACP19143 | Target Name | GAN |
|---|---|---|---|
| Target Synonyms | FLJ38059; GAN (gene name); GAN; GAN_HUMAN; GAN1 (gene name); Gigaxonin; Kelch-like protein 16; KLHL16 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-597 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9H2C0 |
|---|
Uniprot Id
Q9H2C0
Target Species
Human
Target Name
GAN
Target Full Name
Gigaxonin
Target Function
Probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of TBCB. Controls degradation of MAP1B and MAP1S, and is critical for neuronal maintenance and survival.
Target Involvement
Giant axonal neuropathy 1, autosomal recessive (GAN1)
Target Subcellular Location
Cytoplasm. Cytoplasm, cytoskeleton.
Target Tissue Specificity
Expressed in brain, heart and muscle.
Target Synonyms
FLJ38059; GAN (gene name); GAN; GAN_HUMAN; GAN1 (gene name); Gigaxonin; Kelch-like protein 16; KLHL16
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