Recombinant Human GTP-binding protein Di-Ras3 (DIRAS3)

Uniprot Id

O95661

Target Species

Human

Target Name

DIRAS3

Target Full Name

GTP-binding protein Di-Ras3

Target Subcellular Location

Cell membrane; Lipid-anchor; Cytoplasmic side.

Target Protein Families

Small GTPase superfamily, Di-Ras family

Target Tissue Specificity

Expressed in normal ovarian and breast epithelial cells but not in ovarian and breast cancers.

Target Research Area

others

Target Synonyms

DIRA3; DIRA3_HUMAN; DIRAS family GTP binding RAS like 3; DIRAS family GTPase 3; DIRAS family; GTP-binding RAS-like protein 3; DIRAS3; Distinct subgroup of the Ras family member 3; GTP binding protein Di Ras3; GTP-binding protein Di-Ras3; NOEY2; Ras homolog gene family member I; Rho related GTP binding protein RhoI; Rho-related GTP-binding protein RhoI; RHOI

Target Background

This gene encodes a member of the ras superfamily. This gene is imprinted gene with monoallelic expression of the paternal allele which is associated with growth suppression. The encoded protein acts as a tumor suppressor whose function is abrogated in many ovarian and breast cancers. This protein may also play a role autophagy in certain cancer cells by regulating the autophagosome initiation complex.