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| Cat.No | ACP20938 | Target Name | SRGAP3 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Protein Length | Partial | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O43295 |
|---|
Uniprot Id
O43295
Target Species
Human
Target Name
SRGAP3
Target Full Name
SLIT-ROBO Rho GTPase-activating protein 3
Target Function
GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons.
Target Involvement
A chromosomal aberration involving SRGAP3 is found in a patient with severe idiopathic mental retardation (PubMed:12195014). Translocation t(X;3)(p11.2;p25) (PubMed:12195014).
Target Tissue Specificity
Highly expressed in adult and fetal brain. Expressed at low levels in kidney. Isoform 3 is expressed in the kidney but is absent in the brain.
Target Synonyms
ARHGAP 14; ARHGAP14; Gbi; ME GAP; MEGAP; Mental disorder associated GAP; Mental disorder-associated GAP; Rho GTPase activating protein 14; Rho GTPase-activating protein 14; SLIT ROBO Rho GTPase activating protein 3; SLIT-ROBO Rho GTPase-activating protein 3; srGAP 2; srGAP 3; srGAP2; srGAP3; SRGP 2; SRGP2; SRGP3_HUMAN; WAVE associated Rac GTPase activating protein; WAVE-associated Rac GTPase-activating protein; WRP
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