Recombinant Human Superoxide dismutase [Mn], mitochondrial (SOD2)

Uniprot Id

P04179

Target Species

Human

Target Name

SOD2

Target Full Name

Superoxide dismutase [Mn], mitochondrial

Target Function

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Target Involvement

Microvascular complications of diabetes 6 (MVCD6)

Target Subcellular Location

Mitochondrion matrix.

Target Protein Families

Iron/manganese superoxide dismutase family

Target Synonyms

Indophenoloxidase B; IPO B; IPOB; Manganese containing superoxide dismutase; Manganese SOD; Manganese superoxide dismutase; Mangano superoxide dismutase; Mn SOD; Mn superoxide dismutase; MNSOD; MVCD6; SOD 2; SOD2; SODM_HUMAN; Superoxide dismutase [Mn] mitochondrial; Superoxide dismutase [Mn], mitochondrial; Superoxide dismutase 2 mitochondrial

Target Background

This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 1.