Recombinant Human Prefoldin subunit 3 (VBP1)

Uniprot Id

P61758

Target Species

Human

Target Name

VBP1

Target Full Name

Prefoldin subunit 3

Target Function

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

Target Subcellular Location

Cytoplasm. Nucleus. Note=In complex with VHL can translocate to the nucleus.

Target Protein Families

Prefoldin subunit alpha family

Target Tissue Specificity

Ubiquitous.

Target Synonyms

HIBBJ 46; HIBBJ46; PFD 3; PFD3; PFD3_HUMAN; PFDN 3; PFDN3; Prefoldin 3; Prefoldin subunit 3; Prefoldin3; VBP 1; VBP-1; VBP1; VHL binding protein 1; VHL-binding protein 1; Von Hippel Lindau binding protein 1; Von Hippel-Lindau-binding protein 1

Target Background

The protein encoded by this gene interacts with the Von Hippel-Lindau protein to form an intracellular complex. The encoded protein functions as a chaperone protein, and may play a role in the transport of the Von Hippel-Lindau protein from the perinuclear granules to the nucleus or cytoplasm. Alternative splicing and the use of alternate transcription start sites results in multiple transcript variants encoding different protein isoforms.