Recombinant Human Methionine–tRNA ligase, cytoplasmic (MARS), Truncated

Uniprot Id

P56192

Target Species

Human

Target Name

MARS1

Target Full Name

Methionine--tRNA ligase, cytoplasmic

Target Function

Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Plays a role in the synthesis of ribosomal RNA in the nucleolus.

Target Involvement

Interstitial lung and liver disease (ILLD); Charcot-Marie-Tooth disease 2U (CMT2U)

Target Subcellular Location

Cytoplasm, cytosol. Nucleus, nucleolus.

Target Protein Families

Class-I aminoacyl-tRNA synthetase family

Target Synonyms

cytoplasmic; FLJ35667; Mars; Methionine tRNA ligase 1; Methionine tRNA ligase 1 cytoplasmic; Methionine tRNA ligase; Methionine tRNA synthetase ; Methionine--tRNA ligase; Methionyl tRNA synthetase cytoplasmic; Methionyl-tRNA synthetase; MetRS; MRS; MTRNS; SYMC_HUMAN

Target Background

This gene encodes a member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. The encoded protein is a component of the multi-tRNA synthetase complex and catalyzes the ligation of methionine to tRNA molecules.