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| Cat.No | ACP23057 | Target Name | ARSL |
|---|---|---|---|
| Target Synonyms | ARSL; ARSE; Arylsulfatase L; EC 3.1.6.-; Arylsulfatase E; ASE | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 32-589 |
| Protein Length | Full Length of Mature Protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P51690 |
|---|
Uniprot Id
P51690
Target Species
Human
Target Name
ARSL
Target Full Name
Arylsulfatase L
Target Function
Exhibits arylsulfatase activity towards the artifical substrate 4-methylumbelliferyl sulfate. May be essential for the correct composition of cartilage and bone matrix during development. Has no activity toward steroid sulfates.
Target Involvement
Chondrodysplasia punctata 1, X-linked recessive (CDPX1)
Target Subcellular Location
Golgi apparatus, Golgi stack.
Target Protein Families
Sulfatase family
Target Tissue Specificity
Expressed in the pancreas, liver and kidney.
Target Synonyms
ARSL; ARSE; Arylsulfatase L; EC 3.1.6.-; Arylsulfatase E; ASE
Target Background
Arylsulfatase E is a member of the sulfatase family. It is glycosylated postranslationally and localized to the golgi apparatus. Sulfatases are essential for the correct composition of bone and cartilage matrix. X-linked chondrodysplasia punctata, a disease characterized by abnormalities in cartilage and bone development, has been linked to mutations in this gene. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on the Y chromosome.
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