Recombinant Human Aldehyde dehydrogenase family 3 member B1 (ALDH3B1)

Uniprot Id

P43353

Target Species

Human

Target Name

ALDH3B1

Target Full Name

Aldehyde dehydrogenase family 3 member B1

Target Function

Oxidizes medium and long chain saturated and unsaturated aldehydes. Metabolizes also benzaldehyde. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. May not metabolize short chain aldehydes. Can use both NADP(+) and NAD(+) as electron acceptor. May have a protective role against the cytotoxicity induced by lipid peroxidation.

Target Subcellular Location

Cell membrane; Lipid-anchor. Note=Primarily in the plasma membrane as well as in some punctate structures in the cytoplasm.

Target Protein Families

Aldehyde dehydrogenase family

Target Tissue Specificity

Highest expression in kidney and lung.

Target Synonyms

ALDH3B1; ALDH7Aldehyde dehydrogenase family 3 member B1; EC 1.2.1.28; EC 1.2.1.5; EC 1.2.1.7; Aldehyde dehydrogenase 7

Target Background

This gene encodes a member of the aldehyde dehydrogenase protein family. Aldehyde dehydrogenases are a family of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The encoded protein is able to oxidize long-chain fatty aldehydes in vitro, and may play a role in protection from oxidative stress. Alternative splicing results in multiple transcript variants.