Recombinant Human Retinoic acid receptor RXR-beta (RXRB)

Uniprot Id

P28702

Target Species

Human

Target Name

RXRB

Target Full Name

Retinoic acid receptor RXR-beta

Target Function

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE).

Target Subcellular Location

Nucleus. Cytoplasm.

Target Protein Families

Nuclear hormone receptor family, NR2 subfamily

Target Tissue Specificity

Expressed in aortic endothelial cells (at protein level). Expressed in monocytes. Expressed in a variety of tumor cell lines.

Target Synonyms

RXRB; NR2B2; Retinoic acid receptor RXR-beta; Nuclear receptor subfamily 2 group B member 2; Retinoid X receptor beta

Target Background

This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). The encoded protein forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.