Recombinant Human Colorectal mutant cancer protein (MCC), Truncated

Uniprot Id

P23508

Target Species

Human

Target Name

MCC

Target Full Name

Colorectal mutant cancer protein

Target Function

Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation. Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity.

Target Subcellular Location

Cell membrane. Cell projection, lamellipodium. Nucleus. Cytoplasm. Note=Colocalizes with actin at the leading edge of polarized cells.

Target Protein Families

MCC family

Target Tissue Specificity

Expressed in a variety of tissues.

Target Synonyms

Colorectal mutant cancer protein; CRCM_HUMAN; DKFZp762O1615; FLJ38893; FLJ46755; MCC 1; MCC; MCC1; Mutated in colorectal cancers; Protein MCC

Target Background

This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene.