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| Cat.No | ACP23791 | Target Name | HSD17B3 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 1-310 | Protein Length | Full length protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P37058 |
|---|
Uniprot Id
P37058
Target Species
Human
Target Name
HSD17B3
Target Full Name
17-beta-hydroxysteroid dehydrogenase type 3
Target Function
Favors the reduction of androstenedione to testosterone. Uses NADPH while the two other EDH17B enzymes use NADH. Androgens such as epiandrosterone, dehydroepiandrosterone, androsterone and androstanedione are accepted as substrates and reduced at C-17. Can reduce 11-ketoandrostenedione as well as 11beta-hydroxyandrostenedione at C-17 to the respective testosterone forms.
Target Involvement
Male pseudohermaphrodism with gynecomastia (MPH)
Target Subcellular Location
Endoplasmic reticulum.
Target Protein Families
Short-chain dehydrogenases/reductases (SDR) family, 17-beta-HSD 3 subfamily
Target Tissue Specificity
Testis.
Target Synonyms
17 @beta HSD III; 17 beta HSD 3; 17-@beta hydroxysteroid dehydrogenase III; 17-beta-HSD 3; 17-beta-hydroxysteroid dehydrogenase type 3; DHB3_HUMAN; EC 1.1.1.64; EDH17B3; Estradiol 17 beta dehydrogenase ; Estradiol 17 beta dehydrogenase 3; HSD17B3; Hydroxysteroid (17 beta) dehydrogenase 3; OTTHUMP00000021718; SDR12C2; Short chain dehydrogenase/reductase family 12C member 2; Testicular 17 @beta hydroxysteroid dehydrogenase III; Testicular 17 beta hydroxysteroid dehydrogenase ; Testicular 17-beta-hydroxysteroid dehydrogenase; Testosterone 17 beta dehydrogenase 3; Testosterone 17-beta-dehydrogenase 3
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