Rabbit anti-Human PLXNB2 Polyclonal Antibody

The antibody against PLXNB2 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1080-1200 of human PLXNB2 (NP_036533.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-01231A

Number

Cat.No	ADA-01231A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	PLXNB2
Target Synonyms	MM1; PLEXB2; lncFAL; Nbla00445; dJ402G11.3; PLXNB2	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	Mouse kidney, 22Rv1, HepG2, Jurkat, Mouse brain, Mouse liver, Rat liver, SH-SY5Y, SKOV3	Application	ELISA, WB

Cat.No

ADA-01231A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

PLXNB2

Target Synonyms

MM1; PLEXB2; lncFAL; Nbla00445; dJ402G11.3; PLXNB2

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

Mouse kidney, 22Rv1, HepG2, Jurkat, Mouse brain, Mouse liver, Rat liver, SH-SY5Y, SKOV3

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 1080-1200 of human PLXNB2 (NP_036533.2).	Target Species	Human
Immunogen Sequence	ALLRTEAGAFEYVPDPTFENFTGGVKKQVNKLIHARGTNLNKAMTLQEAEAFVGAERCTMKTLTETDLYCEPPEVQPPPKRRQKRDTTHNLPEFIVKFGSREWVLGRVEYDTRVSDVPLSL	Uniprot ID	O15031

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 1080-1200 of human PLXNB2 (NP_036533.2).

Target Species

Human

Immunogen Sequence

ALLRTEAGAFEYVPDPTFENFTGGVKKQVNKLIHARGTNLNKAMTLQEAEAFVGAERCTMKTLTETDLYCEPPEVQPPPKRRQKRDTTHNLPEFIVKFGSREWVLGRVEYDTRVSDVPLSL

Uniprot ID

O15031

Background Information

Uniprot Id

O15031
Target Species

Human
Target Name

PLXNB2
Target Full Name

Plexin-B2
Target Function

Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Plays a role in glutamatergic synapse development and is required for SEMA4A-mediated excitatory synapse development. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May modulate the activity of RAC1 and CDC42.
Target Subcellular Location

Cell membrane; Single-pass type I membrane protein.
Target Protein Families

Plexin family
Target Research Area

Neuroscience
Target Synonyms

PLXNB2; KIAA0315; Plexin-B2; MM1
Target Background

Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002) [PubMed 12183458]).

Rabbit anti-Human PLXNB2 Polyclonal Antibody

Specifications

Immunogen Information

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