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The antibody against INSRR was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 747-921 of human INSRR (NP_055030.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against INSRR was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 747-921 of human INSRR (NP_055030.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-01250A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | INSRR |
| Target Synonyms | IRR; INSRR | Form | Liquid |
| Species Reactivity | Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Rat kidney, Rat pancreas, Rat stomach | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 747-921 of human INSRR (NP_055030.1). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | AAGPLRLGGNSSDFEIQEDKVPRERAVLSGLRHFTEYRIDIHACNHAAHTVGCSAATFVFARTMPHREADGIPGKVAWEASSKNSVLLRWLEPPDPNGLILKYEIKYRRLGEEATVLCVSRLRYAKFGGVHLALLPPGNYSARVRATSLAGNGSWTDSVAFYILGPEEEDAGGLH | Uniprot ID | P14616 |
Uniprot Id
P14616
Target Species
Human
Target Name
INSRR
Target Full Name
Insulin receptor-related protein
Target Function
Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.
Target Subcellular Location
Membrane; Single-pass type I membrane protein.
Target Protein Families
Protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily
Target Synonyms
INSRR; INSRR_HUMAN; Insulin Receptor R; Insulin receptor related receptor precursor; Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain; insulin receptor-related receptor; IR R; IR related receptor; IR-related receptor; IRR; Sir r; Sirr
Target Background
Enables transmembrane receptor protein tyrosine kinase activity. Involved in actin cytoskeleton reorganization; cellular response to alkaline pH; and protein autophosphorylation. Part of receptor complex.
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