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The antibody against FBXO38 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 640-943 of human FBXO38 (Q6PIJ6) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against FBXO38 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 640-943 of human FBXO38 (Q6PIJ6) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-01427A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | FBXO38 |
| Target Synonyms | MOKA; Fbx38; HMN2D; SP329; FBXO38 | Form | Liquid |
| Species Reactivity | Human, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 640-943 of human FBXO38 (Q6PIJ6). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q6PIJ6 | Immunogen Sequence |
Uniprot Id
Q6PIJ6
Target Species
Human
Target Name
FBXO38
Target Full Name
F-box only protein 38
Target Function
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of PDCD1/PD-1, thereby regulating T-cells-mediated immunity. Required for anti-tumor activity of T-cells by promoting the degradation of PDCD1/PD-1; the PDCD1-mediated inhibitory pathway being exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival. May indirectly stimulate the activity of transcription factor KLF7, a regulator of neuronal differentiation, without promoting KLF7 ubiquitination.
Target Involvement
Neuronopathy, distal hereditary motor, 2D (HMN2D)
Target Subcellular Location
Cytoplasm, cytosol. Nucleus.
Target Synonyms
FBXO38; SP329F-box only protein 38
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