Rabbit anti-Human Siglec-8 Polyclonal Antibody

The antibody against Siglec-8 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 17-363 of human Siglec-8 (NP_055257.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-01609A

Number

Cat.No	ADA-01609A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	Siglec-8
Target Synonyms	SAF2; SIGLEC-8; SIGLEC8L; Siglec-8	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	293T, HL-60, Mouse liver, Rat blood	Application	ELISA, WB

Cat.No

ADA-01609A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

Siglec-8

Target Synonyms

SAF2; SIGLEC-8; SIGLEC8L; Siglec-8

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

293T, HL-60, Mouse liver, Rat blood

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 17-363 of human Siglec-8 (NP_055257.2).	Target Species	Human
Uniprot ID	Q9NYZ4	Immunogen Sequence

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 17-363 of human Siglec-8 (NP_055257.2).

Target Species

Human

Uniprot ID

Q9NYZ4

Immunogen Sequence

Background Information

Uniprot Id

Q9NYZ4
Target Species

Human
Target Name

SIGLEC8
Target Full Name

Sialic acid-binding Ig-like lectin 8
Target Function

Putative adhesion molecule that mediates sialic-acid dependent binding to red blood cells. Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. Recognizes simultaneously epitopes having a terminal N-acetylneuraminic acid (sialic acid) and an underlying 6-O-sulfated galactose. Preferentially binds to Gal-6-sulfated sialyl-Lewis X glycan epitopes.
Target Subcellular Location

Membrane; Single-pass type I membrane protein.
Target Protein Families

Immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family
Target Tissue Specificity

Expressed specifically on red blood cells namely basophil, mast cells and eosinophils.
Target Synonyms

CD329 antigen; CDw329; SAF 2; SAF-2; SAF2; Sialic acid binding Ig like lectin 8; Sialic acid-binding Ig-like lectin 8; Sialoadhesin family member 2; SIGL8_HUMAN; Siglec 8; Siglec-8; SIGLEC8; SIGLEC8L
Target Background

Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an association with SLAM-associated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983]).

Rabbit anti-Human Siglec-8 Polyclonal Antibody

Specifications

Immunogen Information

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