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The antibody against MKLN1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 436-735 of human MKLN1 (NP_037387.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against MKLN1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 436-735 of human MKLN1 (NP_037387.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-02178A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MKLN1 |
| Target Synonyms | TWA2; MKLN1 | Form | Liquid |
| Species Reactivity | Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse spleen | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 436-735 of human MKLN1 (NP_037387.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9UL63 | Immunogen Sequence |
Uniprot Id
Q9UL63
Target Species
Human
Target Name
MKLN1
Target Full Name
Muskelin
Target Function
Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Required for internalization of the GABA receptor GABRA1 from the cell membrane via endosomes and subsequent GABRA1 degradation. Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1.
Target Subcellular Location
Cytoplasm. Cytoplasm, cytosol. Nucleus, nucleoplasm. Cell projection, ruffle. Cytoplasm, cell cortex. Cell junction, synapse. Cell junction, synapse, postsynapse.
Target Synonyms
MKLN 1; Mkln1; MKLN1_HUMAN; muskelin 1, intracellular mediator containing kelch motifs ; Muskelin; TWA2; Two-hybrid-associated protein with Ranbpm 2
Target Background
Muskelin is an intracellular protein that acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component thrombospondin I (MIM 188060) (Adams et al., 1998 [PubMed 9724633]).
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