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The antibody against TGM5 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 461-720 of human TGM5 (NP_963925.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against TGM5 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 461-720 of human TGM5 (NP_963925.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
| Cat.No | ADA-02724A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TGM5 |
| Target Synonyms | TGX; PSS2; TGM6; TGMX; TG(X); TGASE5; TGASEX; TGM5 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 293T transfected with TGM5 | Application | ELISA, WB, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 461-720 of human TGM5 (NP_963925.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | O43548 | Immunogen Sequence |
Uniprot Id
O43548
Target Species
Human
Target Name
TGM5
Target Full Name
Protein-glutamine gamma-glutamyltransferase 5
Target Function
Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes.
Target Involvement
Peeling skin syndrome 2 (PSS2)
Target Subcellular Location
Cytoplasm. Note=Associated with intermediate filaments.
Target Protein Families
Transglutaminase superfamily, Transglutaminase family
Target Tissue Specificity
Expressed in foreskin keratinocytes.
Target Synonyms
Protein glutamine gamma glutamyltransferase 5; Protein-glutamine gamma-glutamyltransferase 5; PSS2; TG(X); TGase 5; TGase X; TGase-5; TGase5; TGASEX; Tgm5; TGM5_HUMAN; TGM6; TGMX; TGX; Transglutaminase X; Transglutaminase-5
Target Background
This gene encodes a member of the transglutaminase family. The encoded protein catalyzes formation of protein cross-links between glutamine and lysine residues, often resulting in stabilization of protein assemblies. This reaction is calcium dependent. Mutations in this gene have been associated with acral peeling skin syndrome.
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