Rabbit anti-Human SS18 Polyclonal Antibody

Uniprot Id

Q15532

Target Species

Human

Target Name

SS18

Target Full Name

Protein SSXT

Target Function

Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation. Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner.

Target Involvement

A chromosomal aberration involving SS18 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency).

Target Subcellular Location

Nucleus.

Target Protein Families

SS18 family

Target Tissue Specificity

Fairly ubiquitously expressed. Expressed in synovial sarcomas and in other human cell lines. The fusion genes SSXT-SSX1 and SSXT-SSX2 are expressed only in synovial sarcomas.

Target Synonyms

MGC116875; Protein SSXT; Protein SYT; SS18; SSXT; SSXT/SSX4v fusion ; SSXT_HUMAN; Synovial sarcoma translocated to X chromosome; Synovial sarcoma translocated to X chromosome protein; Synovial sarcoma translocation chromosome 18; SYT; SYT SSX1; SYT SSX2; SYT/SSX4v fusion protein; SYTSSX1; SYTSSX2

Target Background

Enables nuclear receptor coactivator activity. Involved in positive regulation of transcription by RNA polymerase II. Part of SWI/SNF complex. Implicated in synovial sarcoma.