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The antibody against WDR48 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 450-677 of human WDR48 (NP_065890.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
The antibody against WDR48 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 450-677 of human WDR48 (NP_065890.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.
| Cat.No | ADA-02820A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | WDR48 |
| Target Synonyms | P80; UAF1; Bun62; SPG60; WDR48 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | A-431, A-549, HT-1080, LO2, Mouse brain, Rat testis, SGC-7901, U-251MG | Application | ELISA, WB, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 450-677 of human WDR48 (NP_065890.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q8TAF3 | Immunogen Sequence |
Uniprot Id
Q8TAF3
Target Species
Human
Target Name
WDR48
Target Full Name
WD repeat-containing protein 48
Target Function
Regulator of deubiquitinating complexes, which acts as a strong activator of USP1, USP12 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. Also activates deubiquitinating activity of complexes containing USP12. In complex with USP12, acts as a potential tumor suppressor by positively regulating PHLPP1 stability. Docks at the distal end of the USP12 fingers domain and induces a cascade of structural changes leading to the activation of the enzyme. Together with RAD51AP1, promotes DNA repair by stimulating RAD51-mediated homologous recombination. Binds single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). DNA-binding is required both for USP1-mediated deubiquitination of FANCD2 and stimulation of RAD51-mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during these processes.; (Microbial infection) In case of infection by Herpesvirus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein (TIP). Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP. In case of infection by papillomavirus HPV11, promotes the maintenance of the viral genome via its interaction with HPV11 helicase E1
Target Subcellular Location
Nucleus. Cytoplasm. Lysosome. Late endosome.
Target Protein Families
WD repeat WDR48 family
Target Tissue Specificity
Ubiquitous.
Target Synonyms
p80; UAF 1; UAF1; USP1 associated factor 1; USP1-associated factor 1; WD repeat containing protein 48; WD repeat domain 48; WD repeat endosomal protein; WD repeat-containing protein 48; WDR 48; WDR48; WDR48_HUMAN
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