Rabbit anti-Human A1CF Polyclonal Antibody

Uniprot Id

Q9NQ94

Target Species

Human

Target Name

A1CF

Target Full Name

APOBEC1 complementation factor

Target Function

Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay.

Target Subcellular Location

Nucleus. Endoplasmic reticulum. Cytoplasm.

Target Tissue Specificity

Widely expressed with highest levels in brain, liver, pancreas, colon and spleen.

Target Synonyms

A1CF; A1CF_HUMAN; ACF ; ACF64 ; ACF65 ; Apo B RNA editing protein ; Apobec 1 complementation factor ; Apobec 1 complementation factor (ACF) (ASP); APOBEC 1 stimulating protein ; APOBEC1 complementation factor; APOBEC1 stimulating protein; APOBEC1-stimulating protein; APOBEC1CF ; ASP ; MGC163391; RP11-564C4.2

Target Background

Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Several transcript variants encoding a few different isoforms have been found for this gene.